2009, Number 3
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Bioquimia 2009; 34 (3)
Microalbuminuria and its association with retinopathy in patients with type 2 diabetes mellitus
Cerón-Sánchez EC, Bocanegra-Alonso A, Acosta-GonzálezRI, Rodríguez-Hernández R, Mier N
Language: Spanish
References: 28
Page: 115-120
PDF size: 52.50 Kb.
ABSTRACT
Type 2 diabetes and its complications are the leading cause of death among adults in Mexico. Furthermore, diabetes complications have a common physiopathology associated with severe renal damage. The purpose of this study was to investigate microalbuminuria as a marker of inflammatory vascular damage and its association with retinopathy in patients with diabetes, and to identify additional metabolic control parameters and hypertension. The sample of this study consisted of 101 patients with diabetes. The main outcome measure was retinopathy. A clinical examination of patients included anthropometric measures, hypertension level and a dilated fundus screening by direct ophthalmoscopy with Goldman contact lens. Additionally, a fasting blood sample was obtained from patients to assess the lipids profile and levels of serum glucose and glucocylated hemoglobin (HbA
1c). Urine samples were obtained for microalbuminuria determination using the fast strip kit Clinitek
® 50. For statistical analyses, the Pearson chi square test was used. A p value ‹ 0.05 was considered significant. Results show that patients with renal damage determined by micro or macroalbuminuria also had some type of retinopathy (DR), no proliferative diabetic retinopathy and normoalbuminuria 18.7% and no proliferative diabetic retinopathy and microalbuminuria 81.2%, (p = 0.001). All patients with macroalbuminuria had retinopathy, although it was a small subgroup of patients. Such association within this small subgroup of patients may be related to other factors such as time of diagnosis. We conclude that microalbuminuria is a strong predictor of retinal damage. Assessing microalbuminuria levels in patients with type 2 diabetes may result in the diagnosis of retinal damage at earlier stages of the disease.
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