2010, Number 6
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Rev Med Inst Mex Seguro Soc 2010; 48 (6)
Rapid immune response against hepatitis B using an accelerated intradermal vaccination schedule
Solórzano-Santos F, Pérez-de la Cruz L, Meléndez-Blanco SP, Álvarez-y Muñoz MT, Huerta-García GC, Miranda-Novales MG, Vázquez-Rosales G
Language: Spanish
References: 30
Page: 603-606
PDF size: 32.87 Kb.
ABSTRACT
Objective: to evaluate serum antibody levels
against HBV in health care workers whom received
an accelerated intradermal vaccination schedule
with micro doses of recombinant vaccine.
Methods: quasi-experimental study without control
group, in healthy health care workers, with no
previous history of immunization against HBV.
Three doses of intradermal vaccine 5 µg (0.25 mL)
at time 0, 2 and 4 weeks were applied. A serum
sample of 5 mL was taken at time 0, 2 and 8 weeks
after the beginning of the scheme. Antibodies
against HBV surface antigen (antiHB) were measured
by ELISA.
Results: fifty one negative anti-HB subjects were
included, 61 % female, mean of age 33 years old.
After the first dose, 28 % of subjects showed
seroprotection levels (a median of 312 mUI/mL). At
the end of the schedule 93 % of the subjects had
anti-HB antibodies, and 78 % had › 10 mUI/mL.
Conclusions: With this accelerated schedule of
HBV vaccination 90 % of the subjects showed
seroconversion. This scheme elicits rapid immune
response and could be useful in post exposure
cases
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