2015, Number 5
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Rev Med Inst Mex Seguro Soc 2015; 53 (5)
Genome-wide association in type 2 diabetes and its clinical application
Esparza-Castro D, Andrade-Ancira FJ, Merelo-Arias CA, Cruz M, Valladares-Salgado A
Language: Spanish
References: 47
Page: 592-599
PDF size: 309.63 Kb.
ABSTRACT
Diabetes mellitus is a complex and chronical disease, which represents
one of the biggest health issues the world, with alarming numbers and
constantly increasing it demands the creation of new diagnostic, therapeutic
and preventive techniques. The complete Genome Wide Association
(GWA) in type 2 diabetes (T2D) is a useful research tool for the
characterization of genetic markers and physiopathogenic pathways,
with potential clinical utility either as a T2D risk prediction or its complications.
In Mexico is necessary to make a comprehensive dissection of
the genetic background of T2D by the complex genetic mosaic of our
population and increase the knowledge of the molecular and pathophysiological
mechanisms that lead to this condition. There are several
genetic studies for the Mexican population, linked to the 1000 genomes
project, which have led to define some specific genetic markers for our
population which are not described in European populations, until the
moment, 78 loci have been associated with T2D. Recently in the global
meta-analysis, with the participation of Mexico, we demonstrated at least
7 new variants associated with T2D.
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